![]() ![]() It is becoming an integral part of disease management and therapy, finding such applications as patient stratification, drug regimen selection, toxicity avoidance, therapeutic monitoring, and detection of predisposition to disease. Pongali Raghavendra, Thammineni Pullaiah, in Advances in Cell and Molecular Diagnostics, 2018 8.10 Final ConclusionsĬMD is expanding beyond just the identification of infections. As molecular diagnostics continues to expand, we discuss its utility in emerging areas including applications of cell-free DNA, gene expression profiling, and pharmacogenomics. We also provide pre- and postanalytic considerations for common applications of molecular techniques. ![]() This chapter addresses the regulations put forth by CLIA and other regulatory agencies that have shaped the implementation of molecular diagnostics. Critical to the success of clinical genomics is the maintenance of good laboratory practices and regulatory adherence, which can be challenging in the face of rapid growth, emerging technologies, and an evolving regulatory landscape. The increased demand for genetic and genomic information has led to the rapid expansion of molecular techniques within clinical laboratories. Molecular diagnostics are increasingly used to guide patient management, from diagnosis to treatment, particularly in the fields of cancer, infectious disease, and congenital abnormalities. Silverman, in Essential Concepts in Molecular Pathology (Second Edition), 2020 Summary In this chapter, we provide an overview of the field of molecular diagnostics and of the molecular diagnostic methods that are described in the chapters that are included in this textbook.Įli S. High-throughput methods, such as next-generation sequencing or genome-wide association studies, provide invaluable insights into the mechanisms of disease, and genomic biomarkers allow physicians to not only assess disease predisposition but also to design and implement accurate diagnostic methods and to individualize therapeutic treatment modalities. All these factors contribute to the identification and fine characterization of the genetic basis of inherited diseases which, in turn, is vital for the accurate provision of diagnosis. Molecular diagnostics is the outcome of the fruitful interplay among laboratory medicine, genomics knowledge, and technology in the field of molecular genetics, especially with significant discoveries in the field of molecular genomic technologies. Molecular diagnostics is referred to as the detection of genomic variants, aiming to facilitate detection, diagnosis, subclassification, prognosis, and monitoring response to therapy. Ansorge, in Molecular Diagnostics (Third Edition), 2017 Abstract The LMI management is formed by the following consultants / laboratory specialists medical immunology: This is the direct consequence of continuous innovation of diagnostics, in which the LMI has a leading national and international position. ![]() This strong connection to external clients (clinicians, laboratories) directly follows from the role of the LMI as national and international reference laboratory for several laboratory tests. In 2016 a total of more than 55,000 tests (in about 21.000 patients) were performed Furthermore, the LMI performs a large number of tests for external laboratories roughly 40% of the total number of laboratory requests is from outside the Erasmus MC. The LMI has over the years obtained a clear and strong position within Erasmus MC as a partner for clinicians ordering laboratory tests for immunological and malignant hematological diseases. The LMI strives to excel in all three main tasks, through performing high quality diagnostics, including state-of-the-art technology / tests, as well as consulting and advising clinicians ordering lab tests actively initiating diagnostic innovation and cutting edge translational research, related to the different areas in the field of medical immunology organizing a broad spectrum of educational activities in the field of medical immunology and immunology in general. organizing a broad spectrum of educational activities in the field of medical immunology and immunology in general.actively initiating diagnostic innovation and cutting edge translational research, related to the different areas in the field of medical immunology. ![]() performing high quality diagnostics, including state-of-the-art technology/ tests, as well as consulting and advising clinicians ordering lab tests.The LMI strives to excel in all three main tasks, through: Being an academic diagnostic laboratory, the Laboratory of Medical Immunology (LMI) has three main tasks, which are clearly connected and interwoven: ![]()
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